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Microcrystalline vs Nano-Hydroxyapatite | Wholesome Dwelling Economist

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Examination of the variations between microcrystalline and nano-hydroxyapatite for defense in opposition to dental caries and remineralizing the enamel.

tooth with a cavity in need of hydroxyapatite

A pattern I’ve observed in latest months is that practical medical doctors and organic dentists are more and more recommending merchandise that comprise nano-hydroxyapatite to their sufferers.

What’s hydroxyapatite, or “HA” as it’s generally abbreviated?

HA is kind of merely floor bone with solely the moisture extracted.

Nothing else is added or eliminated.

Hydroxyapatite Protects and Remineralizes Tooth

Analysis revealed within the scientific literature convincingly demonstrates that hydroxyapatite gives extremely efficient safety in opposition to dental caries. It additionally provides advantages for tooth remineralization. (1, 2)

In reality, the analysis clearly exhibits that hydroxyapatite’s protecting results on the enamel are pretty much as good or higher than fluoride.

Thus, for these wishing to keep away from the organic harm of fluoride publicity, hydroxyapatite is a superb and secure different.

The query is, what kind?

Is the nano-hydroxyapatite that’s in a rising share of fluoride-free, remineralizing oral care merchandise the way in which to go?

Let’s have a look.

Microcrystalline vs Nano

Microcrystalline hydroxyapatite is the type of dehydrated bone that’s floor to as advantageous a particle measurement as will be carried out mechanically.

Nano-hydroxyapatite is one thing else completely…the particle measurement is massively smaller than the microcrystallized type.

How a lot smaller?

“Nano” is 1000 instances smaller than “micro”. (3)

In reality, nanoparticles are so small that they will simply breach the partitions of cells and even the nuclear membrane inside a single cell itself…the place DNA is situated.

Advantages and Dangers

Whereas microcrystalline hydroxyapatite is 100% secure to be used in oral care merchandise (right here’s the place I get mine), it’s best to keep away from the nano model.

Analysis to this point means that there are dangers for mutations to DNA. This happens from the breaching of the nanoparticles previous the nuclear membranes of particular person cells.

Please word that I’m not questioning the analysis on nano-hydroxyapatite.

The advantages are fairly compelling and credible in that it’s certainly useful in defending in opposition to cavities in addition to for remineralization functions.

Nonetheless, there may be RISK in utilizing nano-hydroxyapatite as effectively. Some different practitioners are glossing over these risks by recommending merchandise containing them.

Briefly, progress within the evaluation of well being dangers from nanoparticles, aka “nano-toxicology”, is being far outstripped by the fast advances in nano-technology itself. (4)

Thus, sensible customers can be effectively suggested to make use of warning with merchandise containing nano-hydroxyapatite else they will find yourself as guinea pigs for this know-how.

Whereas anticipated advantages from nano-hydroxyapatite could happen, the uncomfortable side effects may very well be far worse than tooth decay!

Among the dangers from nanoparticles are already recognized within the literature. Dr. Al Danenberg DDS warns about these risks which embrace cytotoxicity, harm, and mutations to mobile DNA. (5)

This happens because of the breaching of the nuclear membrane (not simply the cell membrane as mentioned within the pro-nanoparticle analysis!).

Nano-Hydroxyapatite Is Not Pure

Briefly, the place microcrystalline hydroxyapatite is a pure substance with a particle measurement that the physique acknowledges and might take care of, nano-hydroxyapatite shouldn’t be.

Nano-hydroxyapatite is the artificial type of hydroxyapatite with confirmed advantages however loads of unknown dangers to the integrity of your DNA.

The particle measurement of nano-hydroxyapatite (or any nanoparticle for that matter) is so tiny that it simply breaches the blood-brain barrier in addition to the nuclear member defending the DNA of each cell.


In closing, you will need to know that whereas research present nano-hydroxyapatite to be efficacious, it has not been confirmed secure.

Thus, in the event you want to take pleasure in the advantages of remineralizing hydroxyapatite in your oral care merchandise, stick to firms that solely use the microcrystalline type.

As of this writing, I solely know of 1 firm that gives most of these merchandise.

That is the hydroxyapatite tooth powder that I take advantage of and suggest that incorporates the secure particle (non-nano) type.

Do you like to make your personal tooth powder?

This bag of microcrystalline hydroxyapatite is ideal for the DIY oral care recipes you make at house.

Lastly, what to do with practitioners who’re recommending nano-hydroxyapatite merchandise for you or your kids?

If it had been me on this state of affairs, I might politely say no.

The medical analysis merely doesn’t assist the protection of nanoparticles for human DNA.

hydroxyapatite with tooth brush on blue background


(1, 3) Nano or No-No? Hydroxyapatite Particle Dimension Issues…

(2) Scientific sources of Hydroxyapatite for Oral Well being

(4) Nano-technology and Nano-toxicology

(5) Managing Well being by Minding Your Intestine (and Mouth) Microbiome (beginning at 1:11)

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